Antibodies present in the joints can cause pain even before the onset of rheumatoid arthritis due to autoimmunity which can facilitate the development of new approaches to reduce non-inflammatory pain caused by various autoimmune diseases, according to the researchers from Karolinska Institutet in Sweden, who published their findings in the Journal of Experimental Medicine.

“We all know that inflammation is painful,” says Camilla Svensson, professor at the Department of Physiology and Pharmacology, Karolinska Institutet. “But pain can appear before any sign of inflammation in the joints and can remain a problem after it has healed. Our aim was to find possible mechanisms to explain that.”

 

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